Indonesia needs strong collaboration across disciplines, sectors, and institutions to effectively address the growing threat of emerging and re-emerging infectious diseases (EIDs) and zoonotic diseases. By bringing together government agencies, healthcare providers, researchers, academic institutions, industry partners, and local communities, the country can develop integrated strategies to improve disease identification, early detection, prevention, surveillance, and response. Such a coordinated, One Health approach strengthens national preparedness, enhances information sharing and innovation, and enables Indonesia to better prevent and control infectious disease outbreaks that pose risks to both human and animal health.